The original/genuine version of MonacoPROFILER 4.8.0 and 4.8.3 both work absolutely perfectly in all versions of windows, be it x86 or x64. I have been using the genuine version of PROFILER 4.8.0 (patched) for over 4 years on XP x64, Vista x64 and Win7 x64 with no problems at any time.
Make sure to always update the latest dll file if using an i1Pro/i1IO/Isis/etc. If the dll file is kept up to date, there will be no problems and definitely no need to use any sort of compatibility settings or the like.
If anyone is in need of the patch for the genuine release, or the install file for the genuine release, just let me know.