I have found this for greyscale optimization of profile. It's for i1Profiler only, but discussion under post may provide you with more information to suit this for other profiling package:
And this too:
Also, in manual for basICColor Print, there is a short paragraph mentioning how to load multiple measurements of different targets to create , merged profile for color optimization in general as well as specific colors (company logos and so on). Basically, this is a narrowed version of averaging multiple measurements of and same target, but with difference – as you are not measuring same target but different s ( for colors like ECI2002 and another, like custom for greyscale), you are getting conversion values for specific colors/shades also in profile.
Hope this helps