I use wetransfer for large files, but depending on the client and the nee, google drive is my alternative. as a downloader i really like gett!
I prefer Mega and ge.tt - Mediafire seems to pull files to often and isn't worth the effort IMO.
I prefer ge.tt (no ads, fast, easy) even though i had some problems with clients (using old or outdated) browsers not being able to download.
although wetranser seems to be standard i don't like it at all and prefer to host large files on our own servers.